Insulin-Like Growth Factor-I and Mammographic Breast Density
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چکیده
منابع مشابه
Insulin-like growth factor-I and mammographic breast density.
To the Editor: Diorio and colleagues recently (1) reported a direct association of the percentage of mammographic density with plasma insulin-like growth factor-I (IGF-I) in a large cross-sectional study. As in previous studies (2, 3), this association was stronger in premenopausal women, and findings were interpreted as support for the hypothesis that elevated plasma IGF-I increases breast can...
متن کاملInsulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density.
Some studies have suggested that insulin-like growth factor (IGF) pathway is related to premenopausal breast density, one of the strongest known breast cancer risk factors. This study was designed specifically to test the hypothesis that higher levels of IGF-I and lower levels of IGF-binding protein (IGFBP)-3 are associated with high mammographic breast density among premenopausal but not among...
متن کاملPlasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density.
Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development of breast tissue and possibly in the etiology of breast cancer. Breast density is one of the strongest predictors of breast cancer. In a cross-sectional analysis within the Nurses' Health Study, we compared the associations of plasma levels of endogenous IGF-I and IG...
متن کاملInsulin-Like Growth Factor-I and Breast Cancer Therapy
Targeting hormonal and growth factor signaling pathways has proven to be useful in the treatment of breast cancer. In vitro, animal, and epidemiologic evidence provide a rationale for the relevance of the insulin-like growth factor (IGF) system to breast cancer biology. The IGF system has been implicated in promoting mitogenic, metastatic, and antiapoptotic phenotypes in breast cancer. As a con...
متن کاملInsulin-like growth factor-I and risk of breast cancer.
Background :-Breast cancer is responsible for the death of millions of women worldwide every year. It is widespread in the world and Iraq that become a genuine problem for public health. The etiology of the disease is unknown. Genetic and hormonal factors are involved in the development of breast cancer and progression of the disease. Insulin like growth factor-ӏ (IGF-ӏ) have been implicated as...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2005
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-05-0607